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Investigator, Advanced Data Analytics
Location:
King Of Prussia, PA
Description:
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.Medicine Development and Supply (MDS) is a highly experienced Chemistry, Manufacturing and Controls (CMC) organization accountable for delivering robust, cost effective and competitive products and manufacturing processes spanning the full life cycle of asset development from discovery through commercialization. These activities are delivered through state-of-the art internal facilities as well as strategic external partners. Collectively, the team is accountable for CMC activities encompassing cell line development, cell culture/microbial fermentation, purification development, and drug product/device development. We also pioneer innovative technologies to improve robustness, reduce cost of goods, and improve the patient experience.Within MDS, Biopharm Drug Substance Development (BDSD) is responsible for the development, scale-up, and technology transfer of cell culture and purification processes to manufacturing facilities all over the world. Our aim is to integrate innovative expression and process platforms, automation, data digitalization, and advanced analytics/modeling into the process development workflow. An opportunity has arisen for an 'Investigator, Advanced Data Analytics' to work directly with project teams to deliver on advanced modeling approaches to accelerate development, increase fundamental understanding, improve risk assessments, and deliver more robust processes, products, and regulatory filings. This includes the application of mechanistic, data driven, and hybrid modelling in process design, control strategy identification, and advanced process monitoring & control for large molecule drug substance process development. The role will also work with our advanced data analytics team to incorporate process analytical technology (PAT) such as Raman and Capacitance sensing for real-time process monitoring approaches. As an Investigator, you will be a member of a highly skilled team of scientists and engineers responsible for the development and optimization of cell culture and purification processes. You will be responsible for developing and maintaining advanced process, PAT, and chemometric models that are utilized to monitor and control key aspects of bioprocesses. You will engage with other groups within GSK to progress the deployment of such advanced models in the development, clinical, and commercial space. Although predominantly lab-based, the role also involves important aspects of verbal and written communication and requires good organizational skills as well as a broader scientific knowledge. Both individual and team working are required and therefore the role will suit a scientist with good interpersonal skills, ability to solve complex problems, eagerness to work across boundaries, self-motivation, and an open mindset. Key responsibilities include: As a matrix drug substance project team member, use mechanistic, data driven, and hybrid modelling to efficiently deliver priority team objectives including but not limited to process design, quantitative risk assessment, identification of critical process parameters, design space definition, and implementation of advanced model-based process monitoring and controls. In addition, develop and maintain PAT (such as Raman, Capacitance, FTIR) chemometric models Use engineering, biological, chemical, or materials science knowledge to postulate mechanisms for bioprocess behavior and develop or modify existing mathematical models to describes those mechanisms Perform or provide guidance on model-based lab experimentation and analysis (e.g., chromatography, PAT, purification, upstream bioprocess) required to develop (e.g., parameter fitting) and verify advanced models to accelerate process development Translate mathematical models to computer models using software platforms (e.g., gPROMS, SIMCA, Unscrambler, JMP, etc.) or by writing custom programs (Using MATLAB, Python, R, etc.) Contribute to the adoption of the modeling and PAT strategy for new products and processes and the validation packages to meet regulatory requirements Support CMC-wide adoption of advanced analytics for supporting the portfolio via GSK-wide grand challenges intended to embed modeling as a central pillar of process development Develop and maintain key system modeling platforms. Leverage external expertise and funding through pre-competitive alliances. Serve as a leader in the modeling space by supporting upskilling and real-time support to expand the use of advanced analytics and process modeling across MDS Stay current with new modeling techniques through publications, conferences, and academic and precompetitive collaborations Comply with data integrity requirements for documentation of models, data, results, and conclusions in appropriate repositories, along with the requirements of quality, safety, and policies and procedures and ensure that GSK intellectual property is protected Foster a collaborative working relationship across the MDS organization, R&D pilot plants, and Commercial supply chain Present data and status reports to CMC matrix teams and senior management. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: A PhD in Chemometrics, Chemical Engineering, or a related subject with emphasis on data analytics, process modeling, or mechanistic mathematical modeling Experience in translating mathematical models into computer programs using MATLAB, Python, R, gPROMS, or similar software tools. Experience with bioprocesses, process monitoring and control, data science, and data analytics Experience in statistical science and related software tools that enable sound experimental design and interpretation of models Experience in creating chemometric and mathematical models from wide variety of PAT/spectroscopy data and independently design and execute work plans to support model development. Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience with mainstream chemometric techniques (multivariate classification, calibration, pattern recognition, PCA/PLS) and familiarity with design of experiments concepts and methods Experience in the use of advanced chemometric methods for process modeling (MSPC, MCR) and 'data wrangling' for signal processing and feature extraction Familiarity with other data driven machine learning methods (SVM, ANN, Bayesian modeling) or the application of hybrid empirical/mechanistic modeling. Good interpersonal, organizational, and communication skills. Ability to work within a team and communicate effectively Experience with metabolic modeling and/or analysis of 'omics data Programming experience using languages/platforms such as MATLAB, SIMCA, CAMO Analytics, Python, R, gPROMS etc. Hands-on laboratory experience in biopharmaceutical process development or a related field #LI-GSK Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-XXXX (US Toll Free) or +1 801 567 XXXX (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.PDN-9bfdbbb9-b838-4263-a889-5ccaef766acb
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Investigator, Advanced Data Analytics is a Other Jobs Investigator Job at GSK located in King Of Prussia PA. Find other listings like Investigator, Advanced Data Analytics by searching Oodle for Other Jobs Investigator Jobs.
Investigator, Advanced Data Analytics is a Other Jobs Investigator Job at GSK located in King Of Prussia PA. Find other listings like Investigator, Advanced Data Analytics by searching Oodle for Other Jobs Investigator Jobs.